![]() ![]() In this paper, we present a novel RTK detection pipeline (RTK-PRED) and the Receptor Tyrosine Kinases Database (TyReK-DB). Therefore, the identification of RTKs in multiple organisms, the documentation of their characteristics, and the collection of related information would be very useful. Currently, there is no available database for RTKs providing information about their function, expression, and interactions. Although they are very important for proper cell function, they have been experimentally studied in a limited range of eukaryotic species. Mutations in RTKs have been associated with different types of cancers and other diseases. They control many vital cellular functions and are involved in the regulation of complex signaling networks. Receptor tyrosine kinases (RTKs) form a highly important group of protein receptors of the eukaryotic cell membrane. ![]() ![]() Authors may use MDPI'sĮnglish editing service prior to publication or during author revisions. Submitted papers should be well formatted and use good English. The Article Processing Charge (APC) for publication in this open access journal is 2300 CHF (Swiss Francs). Please visit the Instructions for Authors page before submitting a manuscript. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. All manuscripts are thoroughly refereed through a single-blind peer-review process. Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website. Research articles, review articles as well as short communications are invited. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. All submissions that pass pre-check are peer-reviewed. Manuscripts can be submitted until the deadline. Once you are registered, click here to go to the submission form. Manuscripts should be submitted online at by registering and logging in to this website. We would like to address enzymes that play key roles in regulating cellular processes as part of enzyme-linked receptors, enzymes functioning in post-translational modifications, and enzymes functioning through other controlling and regulatory mechanisms acting on molecular processes and cellular signaling. Moreover, regulatory enzymes are frequently subject to somatic mutations, most often innocuous, but some mutations elicit functional changes that significantly alter enzymatic activity and ligand binding, affecting health as well as clinical treatment with pharmaceuticals. Because of their key biochemical roles and localized binding sites for small molecules and macromolecules, enzymes are often targets of inhibitor drugs in medicine and as tools for probing function. In this Special Issue, we aim to attract articles from a wide scope of studies that explore, e.g., the structure, biochemical, and biological consequences of enzyme functions in health, disease, and also biotechnological applications. Enzymes play a large variety of essential roles in an organism, facilitating the chemical reactions necessary for life’s processes. ![]()
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